Elucidation of the molecular mechanisms involved in remyelination
Researchers in Japan have revealed the molecular mechanism involved in the process of repair to damage of the myelin sheath.
View ArticleDamaged nerve cells communicate with stem cells
Nerve cells damaged in diseases such as multiple sclerosis (MS), 'talk' to stem cells in the same way that they communicate with other nerve cells, calling out for 'first aid', according to new...
View ArticleHow a mutated gene wreaks havoc on white matter
An inherited disease of myelin marked by slow, progressive neurological impairment is caused by mutations of a gene that controls lipid metabolism, a finding that may shed insight into mechanisms to...
View ArticleA supplement for myelin regeneration
Multiple sclerosis patients continually lose the insulating myelin sheath that wraps around neurons and increases the speed of impulses in the central nervous system. Whenever neurons are demyelinated,...
View ArticleSex differences in brain may underlie neurodevelopmental disorders more...
Many early-onset neurodevelopmental disorders, including autism spectrum disorders, are more common in males than females. The origin of this gender bias is not understood, partially due to a major gap...
View ArticleHow multiple sclerosis can be triggered by brain cell death
Multiple sclerosis (MS) may be triggered by the death of brain cells that make the insulation around nerve fibers, a surprising new view of the disease reported in a study from Northwestern Medicine...
View ArticleStudy hints at regeneration of nerve insulation to treat CHARGE birth defects
Research in Nature Neuroscience suggests the possibility of treating a group of genetic birth defects with molecular therapy that would regenerate malformed nerve insulation in the central nervous system.
View ArticleResearchers identify a new cause of inherited neuropathy
Charcot-Marie-Tooth Disease (CMT) is a family of inherited disorders of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many...
View ArticleEnzyme in myelination process could lead to better understanding of...
The removal of the enzyme Dnmt1 during oligodendrocyte progenitor cell (OPC) differentiation in the central nervous system resulted in inefficient myelin formation and neurological deterioration,...
View ArticleResearchers track critical development in the young brain
Much like electricity traveling down wires, nerve impulses in our brain travel along nerve fibers. And just as wires need insulation to function well, nerve fibers, too, rely on a kind of insulation...
View ArticleNew findings on the connections between gut microbiota and the brain
Intestinal bacteria that can boost bravery or trigger multiple sclerosis: An increasing body of research results confirms the importance of the "gut-brain axis" for neurology and indicates that the...
View ArticleStudy finds a key to nerve regeneration
Researchers at the University of Wisconsin–Madison have found a switch that redirects helper cells in the peripheral nervous system into "repair" mode, a form that restores damaged axons.
View ArticleNeural membrane's structural instability may trigger multiple sclerosis
Multiple sclerosis is one of the most devastating neurodegenerative diseases. It affects some 2.5 million people worldwide. It has no known cure.
View ArticleReplacing myelin protects nerve cells, restores function in mouse model of...
Using a mouse model of multiple sclerosis (MS), a research team led by UC San Francisco scientists has demonstrated for the first time that regenerating myelin – the fatty insulating sheath surrounding...
View ArticleFinding your diagnosis in the brave new world of genetics-based medicine
(Medical Xpress)—We've done a number of articles recently about some amazing individuals developing personalized treatments to their own currently uncurable disease. Whether it is a rare orphan disease...
View ArticleMultiple sclerosis: Newly discovered signal mechanism causes T cells to turn...
Multiple sclerosis is an autoimmune disease in which the body's immune system attacks the patient's own cells. In this case, modified T cells destroy the myelin sheath surrounding nerve cells. Myelin...
View ArticleModel helps explain why some patients with multiple sclerosis have seizures
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that affects nearly 2.3 million people worldwide. MS is triggered when the immune system attacks the protective covering...
View ArticleResearchers make major brain repair discovery in fight against multiple...
Queen's University Belfast scientists have discovered that specific cells from the immune system are key players in brain repair – a fundamental breakthrough that could revolutionise the treatment of...
View ArticleGroup investigates how phototherapy combats neuropathic pain
Low-level laser therapy has been shown by recent studies to be a non-invasive and effective alternative for treating neuropathic pain, a chronic condition caused by nerve damage, spinal cord injury or...
View ArticleAltering the immune system to reverse paralysis
In the ultimate betrayal, one's own immune system can turn against the protective sheath that envelops neurons in the brain, leaving the body paralyzed. Researchers have developed an experimental...
View ArticleUse it or lose it
An Ludwig Maximilian University of Munich study reveals that sound-evoked activity of neurons in the auditory system of the mouse increases the thickness of their myelin sheaths - and enhances the...
View ArticleThe environment can become a noninvasive therapeutic approach to bolster...
Those parents you overhear transforming trips to the grocery store into sensory adventures—telling babies too young to babble that broccoli is GREEN, radishes are RED and tangerines are ORANGE—are onto...
View ArticleLeprosy turns the immune system against itself, study finds
Leprosy hijacks our immune system, turning an important repair mechanism into one that causes potentially irreparable damage to our nerve cells, according to new research that uses zebrafish to study...
View ArticleGene immunotherapy protects against multiple sclerosis in mice
A potent and long-lasting gene immunotherapy approach prevents and reverses symptoms of multiple sclerosis in mice, according to a study published September 21st in the journal Molecular Therapy....
View ArticleChild abuse affects brain wiring
Researchers from the McGill Group for Suicide Studies, based at the Douglas Mental Health University Institute and McGill University's Department of Psychiatry, have just published research in the...
View ArticleA little myelin goes a long way to restore nervous system function
In the central nervous system of humans and all other mammals, a vital insulating sheath composed of lipids and proteins around nerve fibers helps speed the electrical signals or nerve impulses that...
View ArticleResearchers report novel complementary effects of estrogen treatment in...
A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in people with multiple sclerosis (MS). The researchers found...
View ArticleMultiple sclerosis—cholesterol crystals prevent regeneration in central...
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, in which the body's own immune cells attack the fatty, insulating myelin sheath surrounding nerve fibers. The...
View ArticleAn innovative PET tracer can measure damage from multiple sclerosis in mouse...
The loss or damage of myelin, a cellular sheath that surrounds and insulates nerves, is the hallmark of the immune-mediated neurological disorder multiple sclerosis (MS). When segments of this...
View ArticleEvidence for myelin sheath remodeling revealed by in vivo imaging
Nerve fibers are surrounded by a myelin sheath. Scientists at the Technical University of Munich (TUM) have now made the first-ever "live" observations of how this protective layer is formed. The team...
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